Pizza night is one of those dinners that just makes life easier because honestly, who doesn't get excited about pizza? This biscuit pizza casserole takes all those cheesy, saucy, pepperoni-filled flavors your family already loves and turns them into an easy, scoopable dinner with a little more balance from ground turkey and turkey pepperoni.
It's cozy, kid-friendly, and simple enough for a busy weeknight, but still hearty enough to keep everyone full. The biscuits gives it that fun bubble-up texture, while the added protein makes it feel more like a complete dinner than just another pizza night.
As a dietitian, I'm always looking for realistic ways to make family favorites feel a little more balanced without taking away the fun. This one does exactly that with familiar ingredients, simple prep, and zero complaints from the pizza-loving crowd.
If you love easy, family-friendly dinners, check out my pizza gnocchi, cornflake chicken tenders, or sweet potato taco skillet next!
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Why You'll Love This Recipe
- Easy pizza night twist: This casserole gives you all the pizza flavor your family loves, but in a warm, scoopable bake that feels a little different from regular pizza.
- Protein-packed: With 26g of protein, ground turkey and turkey pepperoni make this more filling than a classic biscuit pizza bake.
- Easy family dinner: Kids love the pizza flavors and fluffy biscuit pieces, and you'll love that this recipe is ready in under 45 minutes.
Oh, the things you can do with a can of biscuits! Be sure to try my sloppy joe bake, chicken pot pie muffins, and buffalo chicken bombs to make the most of this weeknight shortcut.
Ingredients for Bubble Up Pizza Casserole
This recipe uses simple ingredients to turn pizza night into a cozy, protein-packed casserole.
- Refrigerated biscuit dough: This gives the casserole that soft, fluffy bubble-up texture. Cut the biscuits into small pieces so they bake through evenly.
- Ground turkey: Ground turkey adds lean protein and makes this casserole more filling while still keeping the flavor family-friendly.
- Turkey pepperoni: Turkey pepperoni gives you that classic pizza flavor and meat lovers feel.
- Pizza sauce: Use a thicker pizza sauce if you can because a watery sauce can make the biscuits too soft in the center.
- Mozzarella cheese: Shredded mozzarella melts perfectly and gives the casserole that cheesy pizza pull.
See the recipe card below for the full list of ingredients and measurements.
Substitutions & Variations
You can absolutely make this pizza casserole with biscuits your own based on what your family loves.
- Add chopped ham or Canadian bacon to turn this into a hearty meat lovers pizza casserole.
- Use regular pepperoni instead of turkey pepperoni if your family prefers a classic pepperoni pizza flavor.
- Swap the ground turkey for lean ground beef when you want a richer pizza vibe.
- Stir in bell peppers, mushrooms, onions, or olives to make a colorful supreme pizza casserole.
- Add jalapeños, crushed red pepper flakes, or spicy pepperoni if you want a spicy biscuit pizza casserole with a little kick.
- Try Italian blend cheese, provolone, or shredded parmesan for an extra cheesy pizza bake.
- Serve this casserole with a little ranch, hot honey, or extra pizza sauce for dipping if your family loves a sauce moment.
How to Make Biscuit Pizza Casserole Recipe
Here's how to bring this easy dinner together.
Step 1: Preheat the oven to 375°F and lightly grease a 9x13-inch baking dish with nonstick spray.
Step 2: Add the ground turkey to a large skillet over medium heat and cook until browned and no longer pink, breaking it apart as it cooks. Stir in the pizza sauce and let it warm through.
Step 3: While the turkey cooks, open the refrigerated biscuits and cut each biscuit into 4 small pieces.
Step 4: Add the biscuit pieces to the prepared baking dish in an even layer.
Step 5: Spoon the sauced ground turkey evenly over the biscuit pieces, then sprinkle with mozzarella cheese and top with pepperoni.
Step 6: Bake uncovered for 25 to 30 minutes, or until the cheese is melted and bubbly and the biscuit pieces in the center are cooked through. If the top starts browning too quickly but the center needs more time, loosely cover the dish with foil and continue baking.
Step 7: Let the casserole rest for 5-10 minutes before serving so it can set up and scoop more easily.
Tips For Best Biscuit Pizza Casserole
A few simple tips make this bubble up pizza bake a family favorite!
- Spread the mixture in a 9x13 baking dish so the pizza biscuit casserole has enough room to bake instead of steaming in the middle.
- Drain any extra liquid from the skillet so the ground turkey does not water down the sauce.
- Use just enough pizza sauce to coat everything because too much sauce can make the biscuit pieces soft and gummy. A 14 oz jar is the perfect amount!
- Let the casserole rest for 5 to 10 minutes so the cheesy pizza bake sets up and scoops more easily.
Storage
This biscuit pizza casserole stores well, which makes it great for quick leftovers the next day.
- Refrigerator: Store leftovers in an airtight container in the refrigerator for 3 to 4 days.
- Reheating: Reheat individual portions in the microwave until warmed through, or use the oven or air fryer for crispier biscuit edges.
- Freezer: You can freeze leftovers, but the biscuit texture may soften after thawing.
FAQ
Yes, but I recommend prepping the parts instead of fully assembling it. Cook the ground turkey ahead of time and store it in the refrigerator, then cut the biscuits and assemble the casserole right before baking so the biscuits do not get too soft.
Absolutely! You can add vegetables like bell peppers, mushrooms, onions, spinach, or olives. I recommend cooking watery vegetables first so they do not release too much liquid into the casserole.
The top should be golden, the cheese should be melted and bubbly, and the biscuit pieces in the center should look fluffy instead of wet or glossy. You can check the center with a fork or toothpick if needed.
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Thank you!
Jessie
High Protein Biscuit Pizza Casserole Recipe
Ingredients
- 1 lb lean ground turkey
- 14 oz. jar pizza sauce
- 1 can refrigerated biscuit dough cut into 4 pieces
- 1 ½ cups shredded mozzarella cheese
- 1 oz turkey pepperoni about 16 slices
Instructions
- Preheat the oven to 375°F and lightly grease a 9x13-inch baking dish with nonstick spray.
- Add the ground turkey to a large skillet over medium heat and cook until browned and no longer pink, breaking it apart as it cooks. Stir in the pizza sauce and let it warm through.
- While the turkey cooks, open the refrigerated biscuits and cut each biscuit into 4 small pieces.
- Add the biscuit pieces to the prepared baking dish in an even layer.
- Spoon the sauced ground turkey evenly over the biscuit pieces, then sprinkle with mozzarella cheese and top with pepperoni.
- Bake uncovered for 25 to 30 minutes, or until the cheese is melted and bubbly and the biscuit pieces in the center are cooked through. If the top starts browning too quickly but the center needs more time, loosely cover the dish with foil and continue baking.
- Let the casserole rest for 5 to 10 minutes before serving so it can set up and scoop more easily.
Notes
- If the center still looks doughy after baking, cover loosely with foil and bake another 3 to 5 minutes.
- Use a thicker pizza sauce to keep the casserole from getting watery.
- Cook watery vegetables like mushrooms, peppers, onions, or zucchini before adding them to the casserole.
- Store leftovers in an airtight container in the refrigerator for 3 to 4 days.
- Reheat in the microwave for convenience or in the oven or air fryer for crispier edges.
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